Intranasal oxytocin ineffective for autism in what may be largest trial to date

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

MANUELA PADURARIU1, IULIA ANTIOCH2, ALIN CIOBICA3*, RADU LEFTER2,4, LAURENTIU SIMION5,6 1Grigore T. Popa University of Medicine and Pharmacy, 16, Universitatii Str., 700115, Iasi, Romania 2Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506, Iasi, Romania 3 Alexandru Ioan Cuza University, Faculty of Biology, Department of Research, 11 Carol I Blvd., 700506, Iasi, Romania 4 Center of Biomed...

AdipoRon may be benefit for atherosclerosis prevention

Atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in atheros...

Is Intranasal Administration of Oxytocin Effective for Social Impairments in Autism Spectrum Disorder?

Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism.

Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in part, because existing medications target only associated ASD features. Emerging evidence suggests that the neuropeptide oxytocin (OXT) may be a blood-based biomarker of social functioning and a possible treatment for ASD. However, prior OXT treatment trials have produced equivocal results, perhaps be...

Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial

UNLABELLED BACKGROUND There are no effective medications for the treatment of social cognition/function deficits in autism spectrum disorder (ASD), and adult intervention literature in this area is sparse. Emerging data from animal models and genetic association studies as well as early, single-dose intervention studies suggest that the oxytocin system may be a potential therapeutic target f...